Beilstein J. Org. Chem.2017,13, 1008–1021, doi:10.3762/bjoc.13.100
of the magnetic field [41]. AuNP optical properties have been widely exploited in the design of GAuNPs with interesting applications such as the colorimetric biosensors. Based on the LSPR phenomenon, the controlledaggregation and de-assembling of AuNPs is reflected in a detectable variation of the
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Graphical Abstract
Figure 1:
Schematic overview on the glyco-gold nanoparticles synthetic approaches.
Beilstein J. Org. Chem.2015,11, 792–803, doi:10.3762/bjoc.11.89
macrostructures.
Keywords: coiled-coil peptides; α-helical fibrils; controlledaggregation; gold nanoparticles; multivalency; Introduction
In the past few decades metal and semiconductor nanoparticles, including gold nanoparticles, have gained much interest due to their desirable optical, magnetic, and
the coiled-coil structure and stability. They are mainly occupied by hydrophilic amino acids and therefore play an important role in interactions with other molecules in the surrounding environment.
In a previous study we showed that the coiled-coil model peptide VW05 induces controlledaggregation of
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Graphical Abstract
Figure 1:
Helical wheel representation and sequences of the peptides used in this study.